Thiols as myeloperoxidase-oxidase substrates
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چکیده
منابع مشابه
Thiols as myeloperoxidase-oxidase substrates.
Nine low-Mr thiols were compared with regard to their ability to function as myeloperoxidase-oxidase substrates under conditions where no auto-oxidation of the thiols could be observed. The methyl and ethyl esters of cysteine were found to be about twice as active as cysteamine at pH 7.0, in terms of increased O2 consumption. Cysteine itself was poorly active, whereas glutathione, N-acetylcyste...
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The changes in the oxidation state of the leucocyte enzyme myeloperoxidase, induced by buffer and thiols, were studied with visible-light-absorption spectroscopy. It was concluded that phosphate buffer contains small amounts of H2O2 and that thiols, when added to buffer, induce the generation of minute amounts of superoxide radical anion. These minute amounts of reduced oxygen species are sugge...
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The neutrophil enzyme myeloperoxidase uses H2O2 to oxidize chloride, bromide, iodide and thiocyanate to their respective hypohalous acids. Chloride is considered to be the physiological substrate. However, a detailed kinetic study of its substrate preference has not been undertaken. Our aim was to establish whether myeloperoxidase oxidizes thiocyanate in the presence of chloride at physiologica...
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The discovery of the stimulation of cell division in plant tissues by trace amounts of kinetin, 6(2-furfuryl) aminopurine (11), has resulted in a number of investigations concerned with the effects of this and related compounds on a variety of plant and animal systems (4, 5, 7,9, 10, 12, 13). One system, developed for study of the in situ effect of agents upon the maintenance of normal organiza...
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A variety of purine and azapurine analogues have been shown to serve as substrates for and inhibitors of xanthine oxidase. Thus, in addition to its usual substrates, hypoxanthine and xanthine, and its demonstrated activity on certain pterines (I), pyrimidines (2)) and aldehydes (3), the following purine analogues are oxidized by xanthine oxidase: adenine (4), 2-azaadenine (5), 6-mercaptopurine ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1988
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2530441